Quantum and Hybrid Quantum-Classical Computing Approaches Workshop 2026 Agenda

14:00 Invited Talk
Sam Stanwyck, NVIDIA
NVIDIA Open Quantum Platform & AI for real-time calibration and decoding

Talk will cover the NVIDIA open quantum platform and the use of AI for real-time calibration and decoding of quantum systems.

14:25 Burns Healy, Dell
NVQLink on PowerEdge

We outline the role of classical compute infrastructure in supporting QPU deployments. Until recently, this role was largely limited to orchestrating and optimizing pre- and post-processing workloads, such as ML-driven transpilation and quantum error mitigation. With the advent of NVIDIA’s NVQLink framework, however, we now have the tools to extend classical HPC infrastructure into real-time co-processing, enabling capabilities such as online QPU calibration, error detection, and dynamic circuit execution on HPC hardware co-located with the QPU. We go over the Real-Time Host paradigm and outline the latency results we found from various PowerEdge servers.

14:40 Invited Talk
Amir Shehata, ORNL — Oak Ridge National Laboratory
OpenQSE: From Fragmented Stacks to Interoperable Ecosystems

OpenQSE is a collaborative initiative bringing together vendors, researchers, and platform developers to collectively shape the emerging quantum-HPC software ecosystem. Rather than building yet another stack, OpenQSE works to align existing efforts through shared interfaces and common specifications that promote interoperability across heterogeneous software components. This talk presents the jointly developed landscape of quantum-HPC software stacks and explains how OpenQSE participants are coordinating to reduce fragmentation, improve compatibility, and enable sustainable integration. It will highlight current milestones, lessons learned from cross-vendor collaboration, and the roadmap toward an open set.

15:05 Kevin Kissell, Alice & Bob
Assimilating Quantum: Architecture and Abstractions for Hybrid Quantum HPC 

Quantum computing presents a great opportunity and a significant challenge for scientific computing and HPC: the opportunity of calculations historically impractical on classical systems, and the challenge that quantum information and algorithms are fundamentally different from the classical computing model. This work explores a set of abstractions and integrations for hybrid quantum HPC computation along two principal axes: useful abstraction layering for software, and extensions of classical HPC methods to include quantum processing with minimal perturbation. The talk argues that GPUs are not a useful analogy — classical GPUs and CPUs have far more in common with each other than quantum processors have with either. It postulates that fault-tolerant quantum computing is best enabled by extending classical HPC techniques for heterogeneous parallel programs: a single executable or shared library may contain both classical instructions and quantum gate operations, with classical control invoking composable quantum solvers. The goal is a hybrid executable format and runtime model that scales both quantum and classical resources without re-compilation and re-validation.

15:20 Luigi Iapichino, LRZ — Leibniz Supercomputing Centre
Integrating quantum hardware in an HPC environment: lessons learnt from the Euro-Q-Exa Pilot Phase

The integration of quantum computers into high-performance computing (HPC) environments, encompassing hardware, software, programming models, and operational aspects, is a key element of the Leibniz Supercomputing Centre’s (LRZ) strategy for heterogeneous computing. This talk presents the Friendly User Pilot Phase of Euro-Q-Exa System 1, a 54-qubit superconducting quantum computer manufactured by IQM, operated at LRZ since March 2026 and initially made available to a limited number of invited research teams. The Pilot Phase is based on close collaboration and a tight feedback loop between users and the LRZ team, supporting both improvement of the software environment (built on the Munich Quantum Software Stack) and a deeper understanding of system behaviour during early operation. Usage statistics, selected use cases in computational chemistry and optimisation, and insights into user interaction with a cutting-edge computing resource are discussed. As the system transitions to regular user operation, a perspective is outlined in which Euro-Q-Exa becomes part of a growing ecosystem of European quantum systems, with increasingly aligned access procedures and software environments.

15:35 Invited Talk
Antonio Córcoles, IBM
Overview of a Reference Architecture for a Quantum-Centric Supercomputer 

Considering the pace of progress in quantum computing today in terms of scale and maturity, and as quantum integration becomes more common in HPC data centers, there is a critical need for a new view on hardware and software architectural approaches. Such a design must be viable today yet sufficiently flexible to support future heterogeneous systems. This flexible architecture, integrating QPUs, GPUs, and CPUs, can evolve through three phases: (1) quantum systems as specialized compute offload engines within existing HPC complexes; (2) heterogeneous quantum and classical HPC systems coupled through advanced middleware, enabling seamless execution of hybrid quantum-classical algorithms; and (3) fully co-designed heterogeneous quantum-HPC systems for hybrid computational workflows. In this talk, we will outline a reference architecture and roadmap for these QCSC systems.

16:30 Invited Talk
Oscar Wallis, STFC Hartree Centre — Science and Technology Facilities Council
QRMI — An Open-Source, Vendor-Agnostic Middleware for Quantum Resource Management and Scheduling

The seamless integration of quantum resources into existing HPC infrastructure remains one of the critical challenges for achieving practical hybrid quantum-classical computing at scale. This talk presents the Quantum Resource Management Interface (QRMI), an open-source, vendor-agnostic middleware framework that enables HPC centres to treat quantum devices as first-class, schedulable resources within standard workload managers such as Slurm. QRMI provides a unified abstraction layer that hides the complexity of heterogeneous quantum backend APIs while supporting diverse quantum architectures. Coupled with a Quantum SLURM Spank Plugin, quantum resources are integrated as generic resources (GRES) and managed through the same scheduling, queuing, and policy framework that governs classical HPC workloads. We present the architectural design decisions underlying QRMI, reflecting lessons learned from deployment in operational HPC centres, and showcase a full C++ workflow that orchestrates multiple quantum and classical resources in parallel.

16:55 Lukas Burgholzer et al., Technical University of Munich & MQSC
QDMI Meets IQM: Turning Quantum Hardware into a First-Class HPC Resource 

The adoption of quantum computing in HPC centers is often hindered by the complexity of integrating quantum hardware into existing workflows, exacerbated by vendor-specific software stacks requiring bespoke engineering for each backend and each site. The Quantum Device Management Interface (QDMI) provides a standardized software-hardware boundary that simplifies integration, enabling HPC centers to incorporate quantum computing with minimal disruption. This talk demonstrates a QDMI-compliant device layer using IQM superconducting systems as a case study, and its integration with Slurm-based scheduling and user-facing circuit submission. The framework is validated with an end-to-end Quantum Selected Configuration Interaction (QSCI) workflow showcasing flexibility across local classical resources, cloud-based QPUs, and on-premise quantum hardware. By standardizing the device-management boundary, QDMI reduces integration complexity and provides a foundation for future research on multi-resource orchestration and advanced scheduling policies.

17:10 Aleksander Wennersteen & Aurélien Nober, Pasqal
Towards Practical Hybrid Quantum Computing: Integrating Hardware, Software, and Applications

As quantum computing matures, the central challenge is no longer only improving individual devices, but making quantum systems usable within larger hybrid computing workflows. This requires progress across the full stack, from hardware capability to software integration and application execution. We present a broad overview of recent progress at Pasqal from a full-stack perspective, focusing in particular on the software and systems layer — including the middleware, runtime, and workflow approaches needed to connect neutral-atom quantum processors to practical hybrid execution environments. We then relate this to recent advances at the hardware and application levels, including solving differential equations with logical qubits and using 256 qubits for quantum simulation of a real material.

17:35 Invited Talk
Peter Coveney, UCL — University College London
Real Science on Hybrid Quantum-Classical Computers

This talk explores pioneering research that integrates quantum computing with conventional supercomputing in two distinct domains. In one, we simulate the complex molecular mechanisms of life by focusing on GPCR proteins, which are targets for one-third of all medicines. The second describes how the use of a quantum device enhances the long-time prediction of the spatio-temporal evolution of chaotic dynamical systems beyond that attainable using conventional machine-learning methods. In both of these domains, we depend on close integration of conventional and quantum computers in order to perform our research.